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Poster 2006 download
Abstract Poster 2008:
Use of artemisinin combination therapy (ACT)
and trends in malaria in a village on the Thai-Myanmar Border
Khin Maung Lwin, Julien Zwang, Sakchai Krutsawatchai, Naw Lilly Khiricharon, Stephane Proux, François Nosten
- SMRU (Shoklo Malaria Research Unit)
- PO Box 46, Mae Sot, Tak, Thailand
Objective
To determine the trend in prevalence of P. falciparum and P.vivax over the period 2006-2008 during rainy and dry seasons in a village in Burma with close proximity to Thailand.
Method
Cross sectional surveys were conducted in the dry and rainy seasons of 2006, 2007 and 2008. All the people of the village (Palu) were screened by malaria smear and age, sex, and pregnancy status were recorded. People with fever or history of fever within the last 2 days also had a Paracheckâ and were treated with mefloquine-artesunate for 3 days (MAS3) if positive. For all positive smear results home visitors went back to the household to give the treatment before 48 hours.
Results
972 screenings were performed. The prevalence of P.falciparum decreased from 5.6% in dry season 2006, 6.7% in rainy season 2006, 4.2% in dry season 2007, to 3.3% in rainy season 2008 (P=0.09, test for trend). P.vivax also decreased and the corresponding prevalence were 15.1, 9.8%, 17.3%, 7.4% (P=0.06, test for trend). The overall prevalence of malaria significantly decreased over the period (20.6%, 16.5%, 21.5%, 10.7%, respectively, P=0.007, test for trend). The ratio PF/PV was less than 1 except in adult males in rainy season only. We observed that males were at higher risk for P. falciparum in both seasons.
Discussion
Malaria prevalence remains rampant in this village of the Myanmar border, but the transmission of P. falciparum seems temporally decreasing by the good coverage for early diagnosis and early treatment with MAS3.
